A charm is another word for a rune, enchantment, or method of creating magic item. The Charm of Vanity interacts with the Appearance/Charisma score of the item weilder
Even though I often didn't see my father for months at a time, I know he loved me as much as I love you, Son, and as he once said to me, 'I may not be the best father, but I will always send my prayers when you need them the most,' and that is what I intend to do for you. Remember this, even if you don't see me for a while and want to hate me, I love you.
Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...