“ Poison can only ever be the tool of a murderer - as such, alchemists are tightly regulated by the Crown, and anyone found in posession of an unknown substance is forced to taste it themselves.”
“ You come upon a ruined building in the back section of a city park (or other out of the way area of the city). The ruins are fairly overgrown. All that is really standing is a doorway and its frame. If you pass through the opened door, you travel to a different world. If the door closes, there may not be a doorway back to get you back.”
“ A circus is in town and while parading down the main street the animals suddenly break free from the cages. After surviving and assisting during the breakout the PCs are hired to help with the investigation. Who did this and why?”