Many, perhaps most fantasy lands are monarchies, which can be ruled well when the monarch is a clever and able man or woman devoted to his or her people. But what happens when the monarch is ill, or is tyrannically cruel, or a young child, or is otherwise blatantly unfit to rule? How can he or she be dealt with without risking civil war as powerful nobles fight for the crown?
One of the current political paradigms of the Cosmic Era.
The plague of the Petroleum Era, the true bane of organized government
What if potions and tonics had negative side effects? Potions of increased strength cause violent tempers, or damage joints. What if potions of dexterity caused tremors, or palsy?
What if they were addictive, and had withdrawal symptoms?
Could someone make a bad batch? No one use the brown strength potion!