“ What if some crazy wizard created an artifact that empowered rodents that touched it with one random supernatural power? Preferly right out of the pages of your favorite four-color. (But only one power!) This item does not convey any sort of intelligence boost.”
“ What if potions and tonics had negative side effects? Potions of increased strength cause violent tempers, or damage joints. What if potions of dexterity caused tremors, or palsy?
What if they were addictive, and had withdrawal symptoms?
Could someone make a bad batch? No one use the brown strength potion!”
“ A massive iron key - 2' length, 20lbs forged from the bones and horns of demon-lords. When used with a massive portal - carefully built according to documents found in powerful books of evil knowledge, it will open into the realm of demons and allow them to flood into the world. The applications of this item for villains are obvious. Mortals touching this item directly will suffer very dire consequences.”