“ You find a patch of edible funghi. They taste well and all, no ill effects. UNLESS you consume some beverage, even 3 (three) days after eating it. Then you become really sick with pains, vomiting, all the fancy stuff. As a gift or good meal, it could be a cruel joke or to make sure the heroes spend their time focused on the mission. And the fine soup you had in the inn yesterday could have some in.
(Inspired through a real-world fungus. Was really used to cure alcoholism.)”
“ A group that wished to be 'ever-living' instead was cursed with 'never-dying'. Thier flesh rotted and fell fromthier bones but still they lived on. Now as skeletons they continue thier quest to remove thier curse. As skeletons they differ in that they do not need controlled or summoned. They are fully fledged NPCs with drives or ideas of thier own. Stabbing and slashing weapons would not affect them.”
“ When running a new party, get around the question of plot density by having the first discovery to be a deck of fate, or whatever you call it. If you use a real deck, you should definitely stack it to have the desired outcome, which is to curse the party to attract weird things to happen and involve them. This should not be told to the players at the time, so that they won't just up and try to get themselves 'decursed'. Though quite why they would want to is beyond me.”