“ A village where everyone goes blind sometime during puberty. What could be causing this? Perhaps something in their diet. Or some malignant gene. How would an entire village where only young childen can see function?”
“ On a planet with an ammonia atmosphere, that is inhabited by intelligent aliens, the police carry oxygen spray, that has the same effect on that planet that pepper spray does here.”
“ The heroes stop in a small town ready to restock their traveling supplies and feed for their animals. All of the villagers are starving, and there is no food to be had. If the PCs are quick witted, their noble steeds might be slaughtered for food.”