“ A Deity of some sort has unleashed a plague of bookworms or something like that in the area. Almost all spellbooks are destroyed, along with bardic and historical books.”
“ An alchemist enchanted his equipment to produce even more powerful alchemical compounds, potions and the like. Unfortunately, it is not well-known that he had different sets of equipment for different processes: If the wrong set of gear is used, the result will invariably fail to function. It's not a cursed item, just something that's hard to figure out.”
“ Another real world thing. White tea. Can only be picked two days a year, the two days before the flowers blossom. Could be a similiar plant that...is the deadliest poison known, cure known diseases or psychosis, or a potent herb that just tastes awesome.”