“ Animals have parasites and diseases, so do plants, there are even bacteria that cann dissolve oil spills or plastic or what have you - why couldn't there be a disease living off magic - a magic item could be infected, losing power and speading the plague to other equipment it contacts, while a magic user would slowly lose his powers and contaminate all he works with or casts a spell at...”
“ Consider the idea of spontaneous genesis of life, as used to be belived. What strange kinds of life might arise from modern substances? What kind of vermin would a landfill produce, or an oil spill on the ocean?”
“ When you sleep, your soul briefly returns to the place where it was created/goes to when it dies, and seeks nourishment. Everybody's soul is created with a little link (or you could say a greater entity calls it back) to that place so that it can return easily, but upon death, the soul returns via that and annihilates the link as if returns.
Also, as an added thingy, you could say the entity supplying the link, or residue of the links themselves, (whichever) is the source of all arcane power.”