A fairly blunt, systemic look at The Shattering. For flowery prose, look elsewhere ;)
The only remnant of the Shattering, Lydecker Cain found himself the solitary survivor of a universe that was no more than shards of glass.
Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...