Nuclear war, zombie outbreaks, meteor strikes, economic collapse, alien invasion, no matter how it happens an apocalypse makes for a unique and engaging setting to run a campaign in, even for a jaded GM.
Here’s a few quick tips that can make a good zombie or other post apocalypse game a great one, and keep the group coming back (from the dead?) for more.
"Binding the Life Coil" is an ancient quasi-mystical technique rediscovered to prolong one's life at the expense of one reproductive ability. It is a simple magikal technique that anyone can learn (a skill or feat). The promise of near immortality or a lifespan of a thousand years or more makes everyone want to learn it.
This technique has a price though, the amount of immortality is in direct response to the strength of ones reproductive spirit. Those that have never breed will live longer than those that have. The use of the technique makes conception difficult, if not impossible. So you trade the future of your society for the chance for you to see much of that future.