Nuclear war, zombie outbreaks, meteor strikes, economic collapse, alien invasion, no matter how it happens an apocalypse makes for a unique and engaging setting to run a campaign in, even for a jaded GM.
Here’s a few quick tips that can make a good zombie or other post apocalypse game a great one, and keep the group coming back (from the dead?) for more.
A large river that is continuously covered in a thick layer of fog. There will be either a rope ferry to get across or possibly a boat that is rowed across by worshippers of the water elementals. It is very thick fog to the point where it even muffles voices even at close range and visibility even beyond a foot is almost impossible.