"We just thought the winter was worse'n usual. Turns out we had an unexpected visitor. Wasn't until poor Dave and Glenda... died... that we finally got a clue. By then it was almost too late. You know how many of us'll never be the same? Oh, you doubt me, do you? Look in my eye, son, and tell me what you don't see. Yeah, I thought so. Damned Snow Devil!"
All you need to stop a brain is a bullet.
Poison can only ever be the tool of a murderer - as such, alchemists are tightly regulated by the Crown, and anyone found in posession of an unknown substance is forced to taste it themselves.