“ What if cancer is not an ailment if one has a will powerful enough, and knows what do do. What if one using the right techniques could control it and use it to become immortal, or to grow into something else?”
“ When was the last time a character caught a cold or flu? Real people get them every now and again even with solid heating and dry interiors. Your characters are out in the cold and wet, and even inside is not always dry and warm. Imagine having to stop your dungeon crawl, sitting in a tight defensive position, while you all are feverish.”
“ The greatest tree in the woods has a secret, there is a dungeon under it made from the intricate web of roots. What creatures could reside here? What secrets will the PCs uncover?”