“ You find a patch of edible funghi. They taste well and all, no ill effects. UNLESS you consume some beverage, even 3 (three) days after eating it. Then you become really sick with pains, vomiting, all the fancy stuff. As a gift or good meal, it could be a cruel joke or to make sure the heroes spend their time focused on the mission. And the fine soup you had in the inn yesterday could have some in.
(Inspired through a real-world fungus. Was really used to cure alcoholism.)”
“ What if potions and tonics had negative side effects? Potions of increased strength cause violent tempers, or damage joints. What if potions of dexterity caused tremors, or palsy?
What if they were addictive, and had withdrawal symptoms?
Could someone make a bad batch? No one use the brown strength potion!”
“ When you sleep, your soul briefly returns to the place where it was created/goes to when it dies, and seeks nourishment. Everybody's soul is created with a little link (or you could say a greater entity calls it back) to that place so that it can return easily, but upon death, the soul returns via that and annihilates the link as if returns.
Also, as an added thingy, you could say the entity supplying the link, or residue of the links themselves, (whichever) is the source of all arcane power.”