“ Feral teenagers:
Teenagers who run away from home to live in the wilderness may become feral. As they become more and more feral, they gain some supernatural powers (a la Peter Pan - ability to fly, things they imagine come true - possibly quite powerful), but at the expense of their humanity and ability to speak, comprehend complex subjects, etc. Maybe they have a leader: the most feral of them all.
A regression into a fantasy childlike state.”
“ The secret for immortality has been discovered by an eccentric wizard/mad scientist. Its found you need to reapply once a month. As people stop dying, and the birth rate increases exponentially, people are forced into homelessness, because of the need for food reamins the same, and food is not being produced fast enough to feed the undying population. The PCs have to find the creator and kill him, and destroy production, to save the world from undying, unending torture from hungryness.”
“ A nation was conquered and the conquerers took control and put themselves in all positions of authority. One major problem, the new rulers and the now peasant/ruled class speak entirely different languages.”