Nuclear war, zombie outbreaks, meteor strikes, economic collapse, alien invasion, no matter how it happens an apocalypse makes for a unique and engaging setting to run a campaign in, even for a jaded GM.
Here’s a few quick tips that can make a good zombie or other post apocalypse game a great one, and keep the group coming back (from the dead?) for more.
"Ladies and Gentlemen of Worth, please come closer and have a look... " In a little stand with numerous maps, the human Advantos sells land-rights with a shining smile and jovial talk at bargain prices. He sells even squatter rights (first to settle is the owner). About 20% of the lands do not exist or belong to someone else. About 30% do not have even that value, or have other problems attached- swampy, cursed, haunted, Old Indian/Pet Cemetery (tm)... Be assured you will not see this man in the same city twice.