Nuclear war, zombie outbreaks, meteor strikes, economic collapse, alien invasion, no matter how it happens an apocalypse makes for a unique and engaging setting to run a campaign in, even for a jaded GM.
Here’s a few quick tips that can make a good zombie or other post apocalypse game a great one, and keep the group coming back (from the dead?) for more.
In the days of old, before the dominance of humanity, the giants were the supreme rulers of the world and their crafts were considered to be the best. These beings venerated the god of the forge above all others and their swords and armors were the best that could be had even in the days of their decline. A hero seeking a masterwork sword might have to voyage long and hard to find a surviving giant smith or cache of rare and valuable giantcraft weapons.