Nuclear war, zombie outbreaks, meteor strikes, economic collapse, alien invasion, no matter how it happens an apocalypse makes for a unique and engaging setting to run a campaign in, even for a jaded GM.
Here’s a few quick tips that can make a good zombie or other post apocalypse game a great one, and keep the group coming back (from the dead?) for more.
Minor Cultural Modifier: The culture believes, for the soul to leave the body, the corpse' eyes must be open. So any member of that culture takes care any dead body they find has its eyes open. Doubly true for those they kill themselves, for then the corpse will surely rise as an undead hunting him.