As gamers we have done the western with laser pistols, six shooters and steam tech. Shadow run alone has covered more noir ground than MGM did between 1945 and 1955. I hope we managed the horror genre well, and the murder mystery almost always sneaks its way into our campaigns. But do we always know we are doing it? Can genre sit right in front of us an yet go undefined? I think it has happened and a speculative fiction genre of all things.
Poison can only ever be the tool of a murderer - as such, alchemists are tightly regulated by the Crown, and anyone found in posession of an unknown substance is forced to taste it themselves.