As gamers we have done the western with laser pistols, six shooters and steam tech. Shadow run alone has covered more noir ground than MGM did between 1945 and 1955. I hope we managed the horror genre well, and the murder mystery almost always sneaks its way into our campaigns. But do we always know we are doing it? Can genre sit right in front of us an yet go undefined? I think it has happened and a speculative fiction genre of all things.
Draw the party together as debtors to the local lord, king, head of the thieves guild, or mercenary clan, who is forcing them to work together to pay off their debts.