As gamers we have done the western with laser pistols, six shooters and steam tech. Shadow run alone has covered more noir ground than MGM did between 1945 and 1955. I hope we managed the horror genre well, and the murder mystery almost always sneaks its way into our campaigns. But do we always know we are doing it? Can genre sit right in front of us an yet go undefined? I think it has happened and a speculative fiction genre of all things.
A village where everyone goes blind sometime during puberty. What could be causing this? Perhaps something in their diet. Or some malignant gene. How would an entire village where only young childen can see function?