“ Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...”
“ A kingdom where, if there are multiple princes (princesses can't rule unless they have no siblings), the princes fight to the death in the arena to decide who gets to rule. A simple way to make sure your brother cannot make a bid for the thrown, and keeps the royal blood in one line.”
“ The multiple-worlds theory of cosmology allows room for every religion's Heaven and Hell and other planes to coexist, with the similar planes of all the sapient beings of all the worlds in all the galaxies...How often do the wires get crossed, as it were, leaving your paladin in a Hell for hedonistic lizards, for example.”