“ Rather than making a baddy impossible to hit, consider giving it mega-hit points.
Super hard to hit leads to great player frustration. Allowing them to do damage leads to a sense of accomplishment. another variation of this would be to give the bad guy a forcefield that shows damage.You could also give them a mastermind ability that sluffs the damage of to minions who should be easy to kill.Once in a while a super high to hit encounter is ok ,but it should be few and far between.
Your mileage may vary”
“ Purple deer have begun to appear near the ruins of a fallen city, or other place of power. Hunting the deer is absurdly easy, as their coloration makes them easy to see. The heros prepare a feast from a freshly killed deer find out several hours later that the meat of the new purple deer is poisonous. This can range from cramps and vomiting to the truly sinister and lethal.”
“ Another real world thing. White tea. Can only be picked two days a year, the two days before the flowers blossom. Could be a similiar plant that...is the deadliest poison known, cure known diseases or psychosis, or a potent herb that just tastes awesome.”