“ As the PCs travel the road, right after a bend they hear a sharp whistle and call: 'Heeey, not so lazy, move your asses!' It is a large man that calls, and there are unwilling workers that listen. A small company, 10-15 men work on the road, push boulders aside, dig up roots from under the road, etc. The large man that shouted turns to you, smiles fast and mutters something under his breath, sounds like cursing some lazy worker. 'Where does the road bring you from, travellers?' And does a little small-talk.
And what is really happening? A group of bandits is 'adapting' the road for shady purposes. The road will not be wider, but tighter, with enough cover around (and a few traps perhaps), and will become an ideal spot for ambushing travellers or entire caravans. The bandit leader wants them all to appear harmless. The 'lazy worker' he cursed was actually a guard that should give warning before any travellers come around (fallen asleep). Not surprisingly, the boss may decide for an ambush even now.”
“ The secret for immortality has been discovered by an eccentric wizard/mad scientist. Its found you need to reapply once a month. As people stop dying, and the birth rate increases exponentially, people are forced into homelessness, because of the need for food reamins the same, and food is not being produced fast enough to feed the undying population. The PCs have to find the creator and kill him, and destroy production, to save the world from undying, unending torture from hungryness.”
“ What if potions and tonics had negative side effects? Potions of increased strength cause violent tempers, or damage joints. What if potions of dexterity caused tremors, or palsy?
What if they were addictive, and had withdrawal symptoms?
Could someone make a bad batch? No one use the brown strength potion!”