“ A village where everyone goes blind sometime during puberty. What could be causing this? Perhaps something in their diet. Or some malignant gene. How would an entire village where only young childen can see function?”
“ While it is within your purview to write long-spanning histories of your world, it is largely unnecessary. If you are running an RPG, do this instead: make a bullet point list of important events that affect the world today, and mysteries that people still don't know. Let these fuel your adventures.”
“ Dust Elemental
https://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=1594
At the corner of air and earth elemental planes resides the dust Elemental, a growing threat to Parisia. With it's powerful choking attack, this creature is a threat to the city. More and more of them are appearing in town, spawned from the many dust devils, a frequent foe of the party, they come in size from 3 HD to 20 HD. Why are there so many? Why in the city?”