“ A Deity of some sort has unleashed a plague of bookworms or something like that in the area. Almost all spellbooks are destroyed, along with bardic and historical books.”
“ While it is within your purview to write long-spanning histories of your world, it is largely unnecessary. If you are running an RPG, do this instead: make a bullet point list of important events that affect the world today, and mysteries that people still don't know. Let these fuel your adventures.”
“ What if cancer is not an ailment if one has a will powerful enough, and knows what do do. What if one using the right techniques could control it and use it to become immortal, or to grow into something else?”