The were-cerberus is a horrific three headed werewolf, and it is a cursed creature
The Totem of Nehual is something of a Maltese Falcon. Many have spent long periods of their life searching for it, spending vast sums of money, and in the end never finding it, or only finding it long enough to lose it.
Game Cliche 2.
Upon learning about "the five ancient jewels" or "the nine legendary icons" or whatever, you can be quite confident that Saving the World will require you to go out and find every last one of them.