“ Mining in a certain area turns all exposed skin (maybe just parts that are actively disturbing the chemicals that cause the reaction) of the those doing the mining to a dark blue color. Will wear off taking as many years/days spent in the mine. ... meeting a party of blue-skinned humans armed with pick-axes etc. Strange disease? Demon offspring? Curse? If they meet only one ex-worker, they will very carefully listen to any stories he says, no matter if drunken or insane, or just makes up to get a beer.”
“ The blood of a dragon is vital in the creation of potions of longevity. The liver could used to cure any disease or ailment, while the heart could restore a PC to full and complete health, despite their age, or injury.”
“ A plague is spreading trough the lands, the plague is actually an old woman carrying a stick. She walks from farm to farm spreading the plague. Can the PCs stop her without getting infected.”