“ Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...”
“ Every now and again, the region encounters a dense blue fog. Every now and again, things disappear into the fog never to be seen again and things appear out of it from other places or world. It seems the fog is the material form of some minor diety charged with moving things around the universe to balance cosmic forces.”