“ Made from the tears of a bound goddess, this magical wine has the power to charm or dominate any who imbibe even the faintest quantity. Once affected, it remains dormant until the victim hears a special magical phrase, upon which they will be magically bound to the speaker. Enterprising villains could drop this into the water supply of an important city..”
“ A casual remark by one of the party about something met on a previous adventure leads to a summons to and grilling by the Mages' Guild (or equivalent), probably resulting in an expedition back to that area to recover the things for study by the Guild. The party's presence will be 'requested' for this expedition.”
“ A massive iron key - 2' length, 20lbs forged from the bones and horns of demon-lords. When used with a massive portal - carefully built according to documents found in powerful books of evil knowledge, it will open into the realm of demons and allow them to flood into the world. The applications of this item for villains are obvious. Mortals touching this item directly will suffer very dire consequences.”