“ Another real world thing. White tea. Can only be picked two days a year, the two days before the flowers blossom. Could be a similiar plant that...is the deadliest poison known, cure known diseases or psychosis, or a potent herb that just tastes awesome.”
“ A weapon of war created by an extinct race, this rat appears normal but is a simulacrum - beneath it's mangy fur is a body of bronze. Commanded by words in a lost language, wherever it goes a virulent and lethal plague follows. The cure is similarly obscure.”
“ Mining in a certain area turns all exposed skin (maybe just parts that are actively disturbing the chemicals that cause the reaction) of the those doing the mining to a dark blue color. Will wear off taking as many years/days spent in the mine. ... meeting a party of blue-skinned humans armed with pick-axes etc. Strange disease? Demon offspring? Curse? If they meet only one ex-worker, they will very carefully listen to any stories he says, no matter if drunken or insane, or just makes up to get a beer.”