“ The Petty Kingdoms is a region consisting of hundreds of small states. Some are kingdoms, some are city states, some are large farming communities, some are duchesses and baronies and so on and so forth. Within a few miles the PCs might reach a new 'country' with completely different rules and norms than the one they left behind. 'What do you eat here? Humans ye say? Lets turn around fellas.'”
“ There is a land where every person wears spectacles. Those without eyeglasses are considered to be the lowest stratum of society, so adventurers without glasses are treated like outcastes. It certainly would explain those heroes wearing sunglasses for no apparent reason...”
“ Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...”