“ Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...”
“ Imagine that all the humanoid and demi-human laguages are actually the same, but pronounced with outrageous accents and bizarre idiom. All the elves have a French accent, all the Dwarves have Swedish, Dragons have a Pakistani accent...”
“ God has been slayed by a mortal man and his head is now worshipped and put on a pedestal. The PCs are hired to steal the head and bring it to a mystic that claims to have the power to revive God.”