“ In an area albinos are considered to be evil mystics and locals ward themselves against them by turning their backs to them to avoid being mesmerized. Suddenly the angeliclly pale loner with white hair and violet hued-eyes is suddenly an outcast, and his companions are treated as if they have been mystically bonded into his service, and could be treated with attempts to intervene or given the same stony treatment. Expect poor quarters, no hospitality and to pay twice as much for everything.”
“ Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...”
“ Animals have parasites and diseases, so do plants, there are even bacteria that cann dissolve oil spills or plastic or what have you - why couldn't there be a disease living off magic - a magic item could be infected, losing power and speading the plague to other equipment it contacts, while a magic user would slowly lose his powers and contaminate all he works with or casts a spell at...”