“ Dust Elemental
https://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=1594
At the corner of air and earth elemental planes resides the dust Elemental, a growing threat to Parisia. With it's powerful choking attack, this creature is a threat to the city. More and more of them are appearing in town, spawned from the many dust devils, a frequent foe of the party, they come in size from 3 HD to 20 HD. Why are there so many? Why in the city?”
“ A planet (or city, valley ect) where those who enter witness protection can escape old age and death itself, so they can live for centuries without aging-provided they maintain their cover perfectly. If they are outed by anyone or ever utter their true name, they age the number of years they have not aged since the day they entered witness protection (which might mean that they age centuries in seconds and crumble into dust and bone.)”
“ Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...”