“ The players encounter an organization dedicated to toppling tyrannous governments; both good and evil. Secretly, they are led by the twin daughters of Lucifer / The Lightbringer / (Generic Adversary God). These daughters have an appropriate set of divine or demonic powers, but strictly speaking, are not evil.”
“ Want to avoid fighter types focusing on swords? Make Longswords and Bastardswords the weapon of the Noble class, with a death penalty for other to carry. These weapons will be ornate and finally crafted. Adventurers will be stuck with cheaply made broad and shortswords, while professional fighters might use two handed swords.”
“ Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...”