“ What if cancer is not an ailment if one has a will powerful enough, and knows what do do. What if one using the right techniques could control it and use it to become immortal, or to grow into something else?”
“ The Pcs discover an ancient, dusty oil lamp, somewhere in the bowels of a dungeon. Naturally they 'rub it', and out pops a wizened, old djinn. So far so good. Then it speaks...
'Ah at last, at last I am free! Now grant me my wish!'
When the PCs explain that they are the ones that should be granted a wish, the malignant djinn explains to them that his particular oil-lamp has a curse placed upon it. Whomsoever releases the entity inside shall be geased to grant the djinn's wish to the best of their ability.
Groans ensue from the party. The djinn rubs his wrinkled hands, grins, and proceeds to name his wish. What could it be?”
“ A friendly human hunter has a talk with you about what you are doing here, and how is the weather. He advises you to not disturb the animals, tend to any fire you set, etc. This is actually a werewolf checking his territory, and if you are not to his liking, he may ambush you with his pack later.”