“ Made from the tears of a bound goddess, this magical wine has the power to charm or dominate any who imbibe even the faintest quantity. Once affected, it remains dormant until the victim hears a special magical phrase, upon which they will be magically bound to the speaker. Enterprising villains could drop this into the water supply of an important city..”
“ Rather than making a baddy impossible to hit, consider giving it mega-hit points.
Super hard to hit leads to great player frustration. Allowing them to do damage leads to a sense of accomplishment. another variation of this would be to give the bad guy a forcefield that shows damage.You could also give them a mastermind ability that sluffs the damage of to minions who should be easy to kill.Once in a while a super high to hit encounter is ok ,but it should be few and far between.
Your mileage may vary”