One of the most powerful tools found in the World Building 102b article is the Worksheet. Here is a place to put the settings you might make with them.
During a storm the PCs come upon a little boy that plays in the rain. Upon further inspection they discover that he has one eye and a long tongue lolling in its mouth. Spit dripping. It is a demon from beyond that can access our realm during storms, it eats all heads that are not its own, living and dead.
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When mans’ smallest, and most deadly, enemy strikes the world is thrown back into a darker, more primitive age.
A post-apocalyptic setting for any system.