“ A village where everyone goes blind sometime during puberty. What could be causing this? Perhaps something in their diet. Or some malignant gene. How would an entire village where only young childen can see function?”
“ Actually a real-world fungus, just heard about it. A fungus that tastes well and all, no ill effects. UNLESS you consume some beverage, even 3 (three) days after eating it. Then you become really sick, pains, vomiting, all the fancy stuff. Was really used to cure alcoholism. May be a joke or to make sure the heroes spend their time focused on the mission.”
“ A secret MLM (pyramid) company that offers eternal life, but in fact it transfers the life forces of its members to those position 'above'. If you get high enough, (meaning you get enough new members) you start to enjoy the benefits. Maybe a willing sacrifice is much more effective for the transfer. But no one says, that a suddenly unwilling member, threatening to tell the authorities, may not loose it involuntarily... thus start people to vanish, and aged corpses are deposited somewhere safe.”