“ What if potions and tonics had negative side effects? Potions of increased strength cause violent tempers, or damage joints. What if potions of dexterity caused tremors, or palsy?
What if they were addictive, and had withdrawal symptoms?
Could someone make a bad batch? No one use the brown strength potion!”
“ Draw the party together as debtors to the local lord, king, head of the thieves guild, or mercenary clan, who is forcing them to work together to pay off their debts.”
“ One of the camels in the caravan trips over a dark rock protruding from the sandy dunes. The poor animal has broken its leg and cannot continue. A cacaphony ensues as the animal suffers and the caravan train overseers complain passionately as they redistribute the animal's load across the caravan. (Let's just hope none of the PC's was riding this camel, shall we?)
As the camel is put out of its misery and the camel is skewered over a campfire - waste nothing! - someone takes a minute to inspect the root cause of all the trouble. To their surprise, the upturned rock is worked stone. Some frantic digging may excavate the bottom half of a gorgeously worked1 obelisk, and maybe even the small square forum below; but a more rigorous exploration of the surrounding dunes reveals a buried tomb doorway on each side of the forum.”