“ When was the last time a character caught a cold or flu? Real people get them every now and again even with solid heating and dry interiors. Your characters are out in the cold and wet, and even inside is not always dry and warm. Imagine having to stop your dungeon crawl, sitting in a tight defensive position, while you all are feverish.”
“ Every now and again, the region encounters a dense blue fog. Every now and again, things disappear into the fog never to be seen again and things appear out of it from other places or world. It seems the fog is the material form of some minor diety charged with moving things around the universe to balance cosmic forces.”
“ Unbeknownest to the character, he is in the royal bllodline. Suddenly the majority of royals fall ill and die, and the hero is left with the crown, but no experience or idea of what to do.”