“ The members of the party has unknowingly been infected by a mysterious plague and have been spreading the virus for quite some time now while adventuring. They start to hear rumors of all the cities in quarantine after they travelled trough. Will they discover the source of this? Will people start to avoid them, try to kill them?”
“ While it is within your purview to write long-spanning histories of your world, it is largely unnecessary. If you are running an RPG, do this instead: make a bullet point list of important events that affect the world today, and mysteries that people still don't know. Let these fuel your adventures.”
“ A known immortal traveling with the PCs kills an attacker, and is arrested and charged with murder, since immortals cannot kill in self defense, being immortal.”