“ You find a patch of edible funghi. They taste well and all, no ill effects. UNLESS you consume some beverage, even 3 (three) days after eating it. Then you become really sick with pains, vomiting, all the fancy stuff. As a gift or good meal, it could be a cruel joke or to make sure the heroes spend their time focused on the mission. And the fine soup you had in the inn yesterday could have some in.
(Inspired through a real-world fungus. Was really used to cure alcoholism.)”
“ There is a land far to the east that is a great, desolate, near-empty wasteland home only to barbarians, ghosts and monsters. Many nations launche expeditions to this land, seeking to find the rumored-at treasures and riches beyond it's outer fringe.”
“ The PCs are sent with a diplomat to another country to protect him and do his bidding. There may be some espionage, rescuing, downright bullying, etc. Could make a nice medieval, special operations background.”