“ Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...”
“ What is a king to do? A prophesy indicates that a certain person is involved with the death of the king, but the prophesy was unclear as to what role - do they cause it or prevent it.”
“ Have the PCs rping Orcs or Goblins or some other race that normally exists only as things to cut up with swords.”