“ What if cancer is not an ailment if one has a will powerful enough, and knows what do do. What if one using the right techniques could control it and use it to become immortal, or to grow into something else?”
“ The greatest tree in the woods has a secret, there is a dungeon under it made from the intricate web of roots. What creatures could reside here? What secrets will the PCs uncover?”
“ You receive a vision of a rooftop 'somewhere close by', where a rare moss grows; in the vision, you know the moss is suitable for greatly enhancing the effects of certain types of potions. Now go and find that rooftop. Don't fall off. (Of course, rooftop runners *will* be taken for miscreants by the local City Watch....)”