“ A Deity of some sort has unleashed a plague of bookworms or something like that in the area. Almost all spellbooks are destroyed, along with bardic and historical books.”
“ You find a patch of edible funghi. They taste well and all, no ill effects. UNLESS you consume some beverage, even 3 (three) days after eating it. Then you become really sick with pains, vomiting, all the fancy stuff. As a gift or good meal, it could be a cruel joke or to make sure the heroes spend their time focused on the mission. And the fine soup you had in the inn yesterday could have some in.
(Inspired through a real-world fungus. Was really used to cure alcoholism.)”
“ Trapped in his tomb, but alive, the God of Pain awaits his uleashing, said to be at the end of the world, he uses his only powers he can and calls to him 2 people, a man and a women to reliquish him from his prison. The man and the women, decieved by them thinking it a person trapped, go after to help the God of Pain unwittily and let him destroy the world”