“ You find a patch of edible funghi. They taste well and all, no ill effects. UNLESS you consume some beverage, even 3 (three) days after eating it. Then you become really sick with pains, vomiting, all the fancy stuff. As a gift or good meal, it could be a cruel joke or to make sure the heroes spend their time focused on the mission. And the fine soup you had in the inn yesterday could have some in.
(Inspired through a real-world fungus. Was really used to cure alcoholism.)”
“ A certain type of demon cannot not be hit by ranged weapons or attacks. Attacks have to be made up close and personal for the damage to mean something. Ranged attacks are to impersonal.
Possibally a way to make the ranged attacks more meaningful would be to coat the arrow head or what not with the shooters blood. Of course, they'd better be a good shot, otherwise they're wasting arrows and already bleeding to boot.
Spells: wizards might have half or no effect, preist might work due to divine intention.”
“ There exists a prestigious academy with a history going back hundreds of years. Graduates are highly skilled and very much sought after for employment. For purely traditional reasons, the academy requires its students to become proficient in a skill or area of knowledge that has no use in the modern world. This could be Ancient Egyptian, an antiquated form of writing such as shorthand, knowledge of building or repairing antique steam engines, programming COBOL, etc. PCs who graduated from this academy must be sure to have this skill in their repertoire.”