“ A known immortal traveling with the PCs kills an attacker, and is arrested and charged with murder, since immortals cannot kill in self defense, being immortal.”
“ A golden skull contains the spirit of a person who has been magically entrapped in an ethereal undead status by an ancient ritual. The person was boiled alive in a golden mixture until nothing remained of him except the bones, now covered by a golden layer. Whoever has these golden bones, controls the spirit and can command it. It can assault the living with wind and storm. Manipulate objects and communicate with the living. (Inspired by Anne Rice, Servant of the Bones)”
“ Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...”