The players encounter an organization dedicated to toppling tyrannous governments; both good and evil. Secretly, they are led by the twin daughters of Lucifer / The Lightbringer / (Generic Adversary God). These daughters have an appropriate set of divine or demonic powers, but strictly speaking, are not evil.
For you to have a near-death experience, Death must have a near-YOU experience. Take care to treat him well, and you may be rewarded... eventually.
The PCs are accosted in a major city containing at least one famous fortuneteller / prophet of the future. They are informed that their as-yet-unborn child will (insert terrible evil), and that, although they are very sorry, the PC must be executed to keep this from happening.
A terrible teleportation incident makes inter-demihuman chimaera of all the PCs. Quoth Master Adams: 'I teleported home one night / with Ron and Sid and Meg / Ron stole Meg's heart away / and I got Sidney's leg.'
Telepathically linked twins that have the ability to switch places. Literally. They've learned to exploit this 'tag-team' throughly.
What if some crazy wizard created an artifact that empowered rodents that touched it with one random supernatural power? Preferly right out of the pages of your favorite four-color. (But only one power!) This item does not convey any sort of intelligence boost.
Somewhere along the line, someone very powerful lost their marbles. Literally. Possessing a marble allows incredible clarity of thought about a particular related subject.
The old pantheon is dead, starved to death from lack of worship. If a powerful mortal can create a cycle of Faith, he can become a New God, to some limiting point.
Somehow, someway, a band of gnomes learns how to be ninjas. In fine gnomish style, they open an academy to teach this art to other gnomes. Wacky Hijinks ensue. Or the gnomes become some of the finest assassins in the land. Or both.
Meta energy...lent by lunos of the seven skys, father of the dragongods, has the power to alter events, rippling through time and space, no other form of energy is stronger, with the ability to even destory planets.It rips apart sheilds by going back in time before they were brought up. No weapon can withstand the force of such It is a power usable only by families bloodline, and those we have chosen to gift with miniscule amounts of its power. It not being of this plane, isn't even subjective to the so called "gods" here. Different worlds, different levels of power.
It is a power of change and manipulation, essentially leaving us to create with it what we will, if our mind is strong enough to do so.
Large amounts of this inserted into any one being/energy will cause them to implode, ripping themselves apart and sucked into another dimension entirely.
The limitations of meta are only set by ones mind, an open mind has no limits to the powers of meta.