Mining in a certain area turns all exposed skin (maybe just parts that are actively disturbing the chemicals that cause the reaction) of the those doing the mining to a dark blue color. Will wear off taking as many years/days spent in the mine. ... meeting a party of blue-skinned humans armed with pick-axes etc. Strange disease? Demon offspring? Curse? If they meet only one ex-worker, they will very carefully listen to any stories he says, no matter if drunken or insane, or just makes up to get a beer.
Diseased people, (leprosy or any other such fear inducing disease) when traveling, will often times wear a cloak that entirely covers their body and ring a bell as they travel, used as a warning for any others to stay away. Could be used for a disguise or safe passage. ... you meet strangely cloaked people, sometimes ringing a bell. "Please give us something to eat, mighty heroes!" This is time to show how good they are.
Herbalist in the group mistakes one plant for another and mistakenly poisons the group. Not to death, but pretty darn ill with recurring symptoms until the cause and cure are realized. (Local people may be able to help rather easily. "You ate Dragon's Rot you fool, looks and smells just like mint except it has these small thistles on the root. Only grow in the Hornwood Forest, that must be where ya got them. Eat this and you will feel better in 4 hours."
PCs camp for the night in a dry pine forest. Fire skill of the person that made it is usually pretty good, but during the first watch the unexpected happens: a spark lights the surrounding woods and a brush fire quickly starts. Be quick or it could turn into a disaster that could affect the entire region.
Could come across a band of refugees. Could have been thrown out of their town by a tyrant taking of their land, bought out by somebody unexpectedly, fleeing a battle they know is coming their way. Could be proof of what they are searching for, hints and tips of what is to come, or just to broaden the reality of the world.
Young kid from last town has been following the PCs and doing a rather good job at it. PCs weren't expecting to be followed so weren't worried and the boy/girl was careful. Notice the follower a couple days out of town, kid ran out of food and started getting careless. Followed the 'mighty adventurers' to see if he could join them. Father is a wealthy merchant. Bring him home, bring him with, send him off? What do you do with an unwelcomed guest.
Rain slowly builds, thunder and lightning continue to roll in. Road muddies, horse/wagon getting stuck in the mud. Thunder strikes coinciding with a deep hole a horse just walked in, horse panics, breaks its leg (maybe just sprain?). Horse is decompacitated and the rain just went from pouring to an all out monsoon. Shelter needs to be found, horse needs to be taken care of, covered in mud, add the posibility of items being lost to the confusion with the wind and dealing with spooked animals.
The journey had been a long one and now they had entered the mountains. After an entire day spent on paths cut into the mountainside and through moss covered coniferous woods, they encounter a desperate young mountain tribal. He is searching for his beloved wife and his elder brother, both of whom he got separated from after an unsuccessful attempt to kill a cave bear. The last thing he saw was the cave bear in full pursuit of his wife. He could not help her as he had been knocked to the ground by the raging beast, and was struggling to regain full consciousness. The tribal will be clearly nervous and urges them to look for his wife during their travels. He will stay in his village a couple of miles to the north and pleads for assistance should they recover his wife, whether she be dead or alive.
On the next day of travel, they will journey upon a dim track in the forest and while they are preparing to ascend another path cut into the mountainside, they hear moans of lust from somewhere nearby. Upon closer inspection they will spy a young tribal woman in the heat of the act with an elder tribal male. They are consummating their forbidden love on the cold mountain moss, and beside them lay the skinned and slaughtered carcass of a huge bear.