When a miracle is worked, when a God turns His attention to the mortal realm, the mortal realm is irrevocably changed by the Divine Presence. When this takes place through a living being, they become the Godmarked. Ever with one foot in life, and one foot in the realm beyond, they are emotionally and physically altered - always in a fashion that reflects the nature of the God that they have channeled - One who channels a God of the Winds may forever have a breeze lifting their hair, while a Goddess of Anger may blacken the skin and strengthen the body.
A massive iron key - 2’ length, 20 lbs forged with demonic faces from the bones and horns of demon-lords. When used with a massive portal - carefully built according to documents found in powerful books of evil knowledge, it will open into the realm of demons and allow them to flood into the world. The applications of this item for villains are obvious. Mortals touching this item are subject to [Effects_of_Touching_Powerful_Evil_Artifacts]
As population increases, animal souls are promoted to human before they are spiritually advanced enough in terms of impulse control, etc.: this shouldn't have happened, but karmic progression is automatic, after all--it's a force of nature. But the 'animalization' of humankind bodes ill for civilization.
No doubt the same goes for elves, dwarves, and so on.