Actually a real-world fungus, just heard about it. A fungus that tastes well and all, no ill effects. UNLESS you consume some beverage, even 3 (three) days after eating it. Then you become really sick, pains, vomiting, all the fancy stuff. Was really used to cure alcoholism. May be a joke or to make sure the heroes spend their time focused on the mission.
Plant that is likely to produce allergic reactions in almost everybody, even by touch. Usage: medicinal, in very exotic foods, non-lethal traps, disabling opponents (have you ever cut an onion,anyway?), spell components, etc.
A local fungus-breed explodes if hit or fallen upon. If there is any conflict between inteligent enemies,both sides are likely to use it to their advantage.
What if the sources of precious metal in the realm all failed, so that the only sources for gold and other precious metal were hostile foreign lands? Gold coinage might become increasingly rare, resulting in hoarding. Player characters that appear with masses of treasure might be suspected of being in the pay of foreign powers.