Actually a real-world fungus, just heard about it. A fungus that tastes well and all, no ill effects. UNLESS you consume some beverage, even 3 (three) days after eating it. Then you become really sick, pains, vomiting, all the fancy stuff. Was really used to cure alcoholism. May be a joke or to make sure the heroes spend their time focused on the mission.
Plant that is likely to produce allergic reactions in almost everybody, even by touch. Usage: medicinal, in very exotic foods, non-lethal traps, disabling opponents (have you ever cut an onion,anyway?), spell components, etc.
A local fungus-breed explodes if hit or fallen upon. If there is any conflict between inteligent enemies,both sides are likely to use it to their advantage.
War of the Roses as a campaign plot. Two noble lines converge somehow, each line thinks it has the rightful claim to the throne. Deciding this long ago was handled by some divine intervention, requiring both houses to come together at some point. They aren't so willing to get together this time. Civil war, or a new king?