A vicious murder happens in a town that the party happens to pop in at. Under heavy suspicion as they are strangers, the party is forced to discover the perpetrator or have their reputations blackened, especially as more and more murders occur in the town, and mysteriously stop and restart when the party leaves to go kill off that evil necromancer who kidnapped the princess.
The only problem is that a demon, possessing one of the party, is the perpetrator. And the demon makes no signs that its living in the PC's head.
In fact, for all the party knows (except for the possessed person's), their companion is an evil murderer.
Do they try and execute their friend as he's a vicious murderer, and no evidence points to demonic posession? Or do they flee town with him, trusting him, and have their reputations destroyed?
After the PCs defeat (or force the rapid retreat of) a villanous necromancer/demon summoner, they discover a book. This book outlines how to summon a demon whose power increases according to the size of the summoning circle used to summon it. And after the PCs examine a map of the country, they find that the layout of the cities and roads match up with the required summoning circle. In fact, the final road that would complete the circle is currently in construction.
With anyone who can find out about the circle and the ritual to summon the demon able to somehow make the final road/line, and destruction of the cities and roads currently in existence out of the question (unless this is an evil campaign- that removes the moral quandary), how are the PCs going to solve this problem?
The PCs are walking along the road, when suddenly a bunch of bandits attacks. The player's dismiss it has just a random encounter, when they find an ornate ring on the leader, obviously out of place with the seemingly poor bandits, who could only afford cheap leather and weapons. This ring has a symbol on it, which, if researched, sets the PCs on a quest. And from then on, the players don't look at random encounters the same way...
A man was killed somehow and brought back to life. He, uniquely, remembers everything about Death, from the skeleton on the horse that guided him, to the afterlife itself. And the annoying bit where he was wrenched from his jacuzzi. He now has penned the instant best seller, entitled 'To Death and Back: My adventurers beyond the grave.' OR IS IT? Is this man telling the truth, or simply a very good liar? Is it all a fraud?
The secret for immortality has been discovered by an eccentric wizard/mad scientist. Its found you need to reapply once a month. As people stop dying, and the birth rate increases exponentially, people are forced into homelessness, because of the need for food reamins the same, and food is not being produced fast enough to feed the undying population. The PCs have to find the creator and kill him, and destroy production, to save the world from undying, unending torture from hungryness.
A kingdom where, if there are multiple princes (princesses can't rule unless they have no siblings), the princes fight to the death in the arena to decide who gets to rule. A simple way to make sure your brother cannot make a bid for the thrown, and keeps the royal blood in one line.
Teenagers who run away from home to live in the wilderness may become feral. As they become more and more feral, they gain some supernatural powers (a la Peter Pan - ability to fly, things they imagine come true - possibly quite powerful), but at the expense of their humanity and ability to speak, comprehend complex subjects, etc. Maybe they have a leader: the most feral of them all.
A regression into a fantasy childlike state.