I once read a book about a group of people who discovered a hidden temple city in a mountain range, where the Incas-the ancient civilisation of Peru- had fled to when the spanish invaded. When this group found the burial chamber of one of the inca high priests, they unleashed a powerful curse upon them all...
Nearly every primitive culture has had rituals and celebrations to guarantee the proper passage of the seasons and to ensure the fertility of crops and animals. Oversight of these ceremonies was generally the provenance of local kings or priests.
Suppose that the adventurers dispatch one of these fellows. The local peasants may become hysterical, fearing famine and death will stalk the land. Alternatively, they may want one of the new heroes to become king. For a while, this can be a good thing, but the first time that the crops fail, the superstitious locals will want to sacrifice their new leader.