The PCs are accosted in a major city containing at least one famous fortuneteller / prophet of the future. They are informed that their as-yet-unborn child will (insert terrible evil), and that, although they are very sorry, the PC must be executed to keep this from happening.
A terrible teleportation incident makes inter-demihuman chimaera of all the PCs. Quoth Master Adams: 'I teleported home one night / with Ron and Sid and Meg / Ron stole Meg's heart away / and I got Sidney's leg.'
Arakis's zombie problem went largely ignored, because it was believed that the Shai-Hulud (sand worms) would effectively dispose of the undead walkers. Unfortunately the problem grew until the roving herds of sunburnt ghouls threatened the flow of spice. While observing one of the great reanimated masses over take a Harvester from the safety of an ornithopter, an Imperial Zoologists noted that the sand caked flesh eating revenants walked entirely without rhythm.
Shortly after receiving this report the Bene Gesserits claimed to have a solution to Arakis's hellish resurrections. They asserted to the agents of the great houses that the worms could be drawn to the walkers using an ancient sonic weapon. According to the sisters, exposing the zombies to an antediluvian ballad composed by the great master M. Jackson would force them to step in time.