The PCs are accosted in a major city containing at least one famous fortuneteller / prophet of the future. They are informed that their as-yet-unborn child will (insert terrible evil), and that, although they are very sorry, the PC must be executed to keep this from happening.
A terrible teleportation incident makes inter-demihuman chimaera of all the PCs. Quoth Master Adams: 'I teleported home one night / with Ron and Sid and Meg / Ron stole Meg's heart away / and I got Sidney's leg.'
Another real world thing. White tea. Can only be picked two days a year, the two days before the flowers blossom. Could be a similiar plant that...is the deadliest poison known, cure known diseases or psychosis, or a potent herb that just tastes awesome.