The PCs are accosted in a major city containing at least one famous fortuneteller / prophet of the future. They are informed that their as-yet-unborn child will (insert terrible evil), and that, although they are very sorry, the PC must be executed to keep this from happening.
A terrible teleportation incident makes inter-demihuman chimaera of all the PCs. Quoth Master Adams: 'I teleported home one night / with Ron and Sid and Meg / Ron stole Meg's heart away / and I got Sidney's leg.'
There is a land far to the east that is a great, desolate, near-empty wasteland home only to barbarians, ghosts and monsters. Many nations launche expeditions to this land, seeking to find the rumored-at treasures and riches beyond it's outer fringe.