The PCs are accosted in a major city containing at least one famous fortuneteller / prophet of the future. They are informed that their as-yet-unborn child will (insert terrible evil), and that, although they are very sorry, the PC must be executed to keep this from happening.
A terrible teleportation incident makes inter-demihuman chimaera of all the PCs. Quoth Master Adams: 'I teleported home one night / with Ron and Sid and Meg / Ron stole Meg's heart away / and I got Sidney's leg.'
Ten powerful magic rings created by an Archmage have scattered to ten random people (suggest only one is PC). This happened when he died in battle. Whoever gets all ten rings inherites all the power the Archmage invested to them over his 200 year life.